Home infusion nursing: what the job involves and how to get into it
Paloma Talent · Updated October 6, 2026Home infusion nurses are RNs who give IV and other infusion therapies in patients’ homes and teach patients to manage them between visits. They are hired by home infusion pharmacies and home health agencies, and strong IV skills are the main requirement.
Therapies and lines
- IV antibiotics and antifungals
- Immune globulin (IVIG and SCIG)
- Hydration and electrolyte replacement
- Parenteral nutrition (TPN)
- Care of PICC lines, midlines and implanted ports
A typical visit
The nurse assesses the patient, checks the line, starts or changes the infusion, teaches the patient or caregiver, and documents the visit for the pharmacy and physician. Many visits end with the patient running the infusion on a pump until the next visit.
Who hires home infusion nurses
Home infusion pharmacies, which dispense the therapy and employ or contract nurses, and home health agencies that provide infusion services. Roles are full-time, part-time and PRN.
Getting into the specialty
Most home infusion nurses come from ICU, emergency, oncology or infusion-center nursing, where they built confident IV and central-line skills. The CRNI certification is the recognized specialty credential.
Questions
Do I need ICU experience?
Not always. Employers look for confident IV starts and central-line care, which ICU, emergency, oncology and infusion-center nurses usually have.